货号：07-586

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-STAT5A/B (Tyr694/699) Antibody | 07-586 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes phospho-STAT5A/B (Tyr694/699). View All» Molecular Weight: 95 kDa View All» Immunogen: peptide containing the sequence DGpYVK in which pY corresponds to phospho-tyrosine 694 of human STAT5 View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Background Information: The STAT proteins (signal transducer and activator of transcription) comprise a family of transcription factors. STATs are activated through tyrosine phosphorylation, mainly by JAK kinases, which results in their dimerization, nuclear translocation and regulation of gene expression. STAT5 activity is induced by numerous cytokines and growth factors. While STAT5A and STAT5B share 96% amino acid homology, the two isoforms have distinct physiological functions. Phosphorylation of tyrosine 694/699 is a key marker of STAT5A/B activation. View All» Species Reactivity:

• Bovine

• Human

• Mouse

• Rat
  View All» Control: PDGF treated 3T3/NIH cells View All» Quality Assurance: routinely evaluated with lysates from 3T3/NIH cells treated with PDGF View All» Purification Method: Immunoaffinity purified View All» Presentation: Protein A Purified immunoglobulin in 0.1M Tris-Glycine, 0.15M NaCl, 0.05% Sodium Azide, pH 7.4. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number:
  • P42229

  • P51692
    View All» Entrez Gene Number: NM_012448.3 View All» Gene Symbol:
    • STAT5B

    • STAT5
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Dot Blot

      • Western Blotting
        View All» Entrez Gene Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. View All» UniProt Summary: FUNCTION: SwissProt: P51692 # Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.SIZE: 787 amino acids; 89866 Da SUBUNIT: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocated into the nucleus in response to phosphorylation (By similarity).PTM: Tyrosine phosphorylated (By similarity).DISEASE: SwissProt: P51692 # Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy.SIMILARITY: SwissProt: P51692 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-STAT5A/B (Tyr694/699) Antibody | 07-586 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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