货号：07-609

品牌：Merck Millipore

规格：

目录价：￥4399.00

市场价格：￥3739.15

会员价格：￥3519.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Peroxiredoxin 1 Antibody | 07-609 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Peroxiredoxin 1 View All» Molecular Weight: 21kDa View All» Immunogen: peptide corresponding to amino acids 104-115 (LVSDPKRTIAQD) of human Peroxiredoxin 1 View All» Isotype: IgG View All» Species Reactivity: Human View All» Species Reactivity Note: Predicted to cross-react with rat based on homology View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from Du145 cells View All» Purification Method: Serum View All» Presentation: antiserum in 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q06830 View All» Entrez Gene Number: NM_002574 and others View All» Gene Symbol:

• PRDX1

• PAG

• PAGB

• PAGA

• NKEFA

• TDPX2

• MSP23

• NKEF-A

• Peroxiredoxin-1
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunocytochemistry
    View All» Entrez Gene Summary: This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. Three transcript variants encoding the same protein have been identified for this gene. View All» UniProt Summary: FUNCTION: SwissProt: Q06830 # Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).SIZE: 199 amino acids; 22110 Da SUBUNIT: Homodimer; disulfide-linked, upon oxidation (By similarity). May form heterodimers with AOP2.SUBCELLULAR LOCATION: Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.PTM: Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity.SIMILARITY: SwissProt: Q06830 ## Belongs to the ahpC/TSA family.MISCELLANEOUS: The active site is the redox-active Cys-52 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-173-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin. & Inactivated upon oxidative stress by overoxidation of Cys-52 to Cys-SO(2)H and Cys-SO(3)H. Cys-SO(2)H is retroreduced to Cys-SOH after removal of H(2)O(2), while Cys-SO(3)H may be irreversibly oxidized." View All» Brand Family: Upstate View All» Product Name: Anti-Peroxiredoxin 1 Antibody | 07-609 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Serum View All» Host: Rabbit View All»
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