货号：07-611

品牌：Merck Millipore

规格：

目录价：￥4154.00

市场价格：￥3530.90

会员价格：￥3323.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Peroxiredoxin 3 Antibody | 07-611 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Peroxiredoxin 3 View All» Molecular Weight: 21kDa View All» Immunogen: Full-length human Peroxiredoxin recombinant protein tagged with hexahistidine View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from Du145 cells View All» Purification Method: Serum View All» Presentation: antiserum in 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P30048 View All» Entrez Gene Number: NM_006793 and others View All» Gene Symbol:

• PRDX3

• SP-22

• HBC189

• MGC104387

• MER5

• AOP-1

• MGC24293

• Peroxiredoxin-3

• AOP1

• PRO1748
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunocytochemistry
    View All» Entrez Gene Summary: This gene encodes a protein with antioxidant function and is localized in the mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P30048 # Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical- generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol.SIZE: 256 amino acids; 27693 Da SUBUNIT: Homodimer; disulfide-linked, upon oxidation (By similarity). Binds MAP3K13.SUBCELLULAR LOCATION: Mitochondrion.SIMILARITY: SwissProt: P30048 ## Belongs to the ahpC/TSA family. MISCELLANEOUS: The active site is the redox-active Cys-108 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-229-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin. & Irreversibly inactivated by overoxidation of Cys- 108 (to Cys-SO(3)H) upon oxidative stress. View All» Brand Family: Upstate View All» Product Name: Anti-Peroxiredoxin 3 Antibody | 07-611 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 50 µL View All» Format: Serum View All» Host: Rabbit View All»
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