货号：07-618

品牌：Merck Millipore

规格：200Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SF-1 Antibody | 07-618 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes SF-1. View All» Molecular Weight: 53 kDa View All» Immunogen: DNA binding domain of SF-1 from mouse, produced in E. coli as a GST fusion protein and partially purified via GST-agarose column chromatography View All» Isotype: IgG View All» Background Information: Steroidogenic factor-1 (SF-1) regulates multiple genes involved in the adrenal and gonadal development and in the biosynthesis of a variety of hormones, including adrenal and gonadal steroids, anti-Mullerian hormone (AMH), and gonadotropins. SF-1 belongs to the fushi tarazu factor-1 (FTZ-F1) subfamily of orphan nuclear receptors. In the adult ovary, SF-1 localizes to theca/interstitial cells. View All» Species Reactivity: Mouse View All» Control: Y1 cell lysate View All» Quality Assurance: Routinely evaluated by immunoblot on RIPA lysates from Y1 cells View All» Purification Method: Protein A purfied View All» Presentation: Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative. View All» Storage Conditions: Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: Q13285 View All» Entrez Gene Number: NM_004959 View All» Gene Symbol:

• NR5A1

• FTZ1

• FTZF1

• AD4BP

• SF-1

• STF-1

• OTTHUMP00000042845

• SF1

• ELP

• OTTHUMP00000042847

• OTTHUMP00000042846
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. View All» UniProt Summary: FUNCTION: SwissProt: Q13285 # Transcriptional activator. Seems to be essential for sexual differentiation and sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes. 5'- YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1/FTZF1. The SFPQ-NONO-NR5A1/SF-1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3.SIZE: 461 amino acids; 51636 Da SUBUNIT: Binds DNA as a monomer. Interacts with NR0B2 (By similarity). Part of a complex consisting of SFPQ, NONO and NR5A1/SF-1. Interacts with NCOA2.SUBCELLULAR LOCATION: Nucleus.PTM: Acetylation stimulates the transcriptional activity.DISEASE: SwissProt: Q13285 # Defects in NR5A1 are a cause of XY sex reversal with adrenal failure [MIM:184757]. This disease is characterized by normal female external genitalia and retention of the uterus. & Defects in NR5A1 are a cause of adrenocortical insufficiency without ovarian defect [MIM:184757]. The disease is characterized by severe 'slackness,' muscular hypotonia. There is decreased sodium, increased potassium and elevated ACTH.SIMILARITY: SwissProt: Q13285 ## Belongs to the nuclear hormone receptor family. NR5 subfamily. & Contains 1 nuclear receptor DNA-binding domain. View All» Brand Family: Upstate View All» Product Name: Anti-SF-1 Antibody | 07-618 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 μg View All» Format: Purified View All» Host: Rabbit View All»
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