货号：07-624

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-hSNF2H Antibody | 07-624 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Product Overview: The SNF2 family of proteins are ATP dependant chromatin remodeling enzymes. The gene encoding this protein is also known as SMARCA5 View All» Specificity: hSNF2H View All» Molecular Weight: 120kDa View All» Immunogen: peptide corresponding to amino acids 58-77 (MEEIFDDASPGKQKEIQEPD) of human hSNF2H (SWI/SNF-related matrix-associated actin-dependent chromatin a5) View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunoblot in nuclear extracts from HeLa cells View All» Purification Method: Immunoaffinity purified View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 1 year at -20°C View All» UniProt Number: O60264 View All» Gene Symbol:

• SMARCA5

• WCRF135

• hISWI

• hSNF2H

• SNF2H

• HSNF2H

• ISWI
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunoprecipitation

  • Western Blotting
    View All» Entrez Gene Summary: The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein. View All» UniProt Summary: FUNCTION: SwissProt: O60264 # Possesses intrinsic ATP-dependent nucleosome-remodeling activity. Complexes containing SMARCA5 are capable of forming ordered nucleosome arrays on chromatin in vitro; this may require intact histone H4 tails. Also required for replication of pericentric heterochromatin in S-phase specifically in conjunction with BAZ1A. Probably plays a role in repression of polI dependent transcription of the rDNA locus, through the recruitment of the SIN3/HDAC1 corepressor complex to the rDNA promoter.SIZE: 1052 amino acids; 121905 Da SUBUNIT: Catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. Each complex contains subunits which may regulate the specificity or catalytic activity of SMARCA5. ACF/WCRF contains BAZ1A; CHRAC contains BAZ1A, CHRAC1, and POLE3; RSF contains RSF1; WICH contains BAZ1B. SMARCA5 is the catalytic subunit of the NoRC chromatin-remodeling complex, which also contains BAZ2A and of SMARCA5/cohesin/NuRD complexes. The BAZ2A subunit of NoRC also interacts with DNMT1, DNMT3B and HDAC1, which allows NoRC to actively suppress rDNA transcription by a combination of nucleosome remodeling, histone deacetylation, and DNA methylation.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Ubiquitously expressed.DEVELOPMENTAL STAGE: Overexpressed in CD34-positive erythrocyte progenitor cells in acute myeloid leukemia. Down-regulation correlates with hematologic remission following chemotherapy.SIMILARITY: SwissProt: O60264 ## Belongs to the SNF2/RAD54 helicase family. ISWI subfamily. & Contains 1 helicase ATP-binding domain. & Contains 1 helicase C-terminal domain. & Contains 2 SANT domains. View All» Brand Family: Upstate View All» Product Name: Anti-hSNF2H Antibody | 07-624 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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