货号：07-632

品牌：Merck Millipore

规格：200Ug

目录价：￥6588.00

市场价格：￥5599.80

会员价格：￥5270.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NR2A Antibody | 07-632 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes NR2A, MW ~170 kDa. View All» Molecular Weight: ~170 kDa View All» Immunogen: 6His-tagged fusion protein corresponding to amino acids 1265-1464 of mouse NMDA receptor 2A (NR2A). View All» Isotype: IgG View All» Background Information: NR2 or glutamate receptor, ionotropic, N-methyl D-aspartate 2 (NMDA2; NMDAR2) along with the NR1 subunit forms a heterodimer that make up the NMDA receptor. By alternative splicing there are various isoforms of NR2 classified as NR2A through D. The NMDA receptor (NMDAR) is characterized as a ionotropic receptor for glutamate. As the name suggests, (NMDA (N-methyl D-aspartate) is an agonist for the receptor. A distinct characteristic of the NMDA receptor is that it is both ligand-gated and voltage-dependent based on its sensitivity to magnesium. The NR1 subunit binds glycine while the NR2 subunit binds glutamine for activation. Activated NMDA receptors result in the opening of an ion channel that is nonselective to cations. The result is the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell. Calcium flux by the NMDARs has been implicated in synaptic plasticity, a mechanism in the cell for learning and memory. View All» Species Reactivity:

• Mouse

• Rat
  View All» Application Notes: Immunoprecipitation: 4 µg of a previous lot immuno-precipitated NR2A from rat brain hippocampus membranes and rat brain microsomal preparations. View All» Control: Brain tissue. View All» Quality Assurance: Evaluated by western blot in rat brain microsomal preparations (Catalog # 12-144).Western Blot Analysis: 0.5-2 µg/mL of this antibody detected NR2A in rat brain microsomal preparations (Catalog # 12-144). View All» Purification Method: Protein A purfied View All» Presentation: Purified rabbit polyclonal IgG in buffer containing 70% storage buffer 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide and 30% glycerol. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: Q12879 View All» Entrez Gene Number: NM_008170 View All» Gene Symbol:
  • GRIN2A

  • hNR2A

  • Glutamate

  • NMDAR2A

  • NR2A
    View All» Alternate Names:
    • N-methyl D-aspartate receptor subtype 2A

    • N-methyl-D-aspartate receptor channel, subunit epsilon-1

    • N-methyl-D-aspartate receptor subunit 2A

    • NMDA receptor subtype 2A

    • glutamate receptor, ionotropic, N-methyl D-aspartate 2A
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunoprecipitation

      • Western Blotting
        View All» Entrez Gene Summary: N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). View All» UniProt Summary: FUNCTION: SwissProt: Q12879 # NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.SIZE: 1464 amino acids; 165283 Da SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of AIP1, INADL and DLG4 (By similarity).SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.SIMILARITY: SwissProt: Q12879 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family. View All» Brand Family: Upstate View All» Product Name: Anti-NR2A Antibody | 07-632 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 μg View All» Format: Purified View All» Host: Rabbit View All»
        © 金山科研平台是专业的授权总代理区域代理经销平台。
        © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
        © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
        © 本文地址：https://www.16ao.com/thread-136106.htm
        © Merck Millipore代理07-632 Anti-NR2A Antibody;抗-NR2A抗体store at +2℃ to +8℃，产品报价联系微信jinshanbio