金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Arg72-Asp316, with an N-terminal 6-His tag Accession #:O35235 N-terminal Sequence Analysis:His Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:28 kDa SDS-PAGE:36 kDa, reducing conditions Activity:Measured by its ability to induce osteoclast differentiation of RAW264.7 mouse monocyte/macrophage cells.The ED₅₀ for this effect is typically 5-15ng/mL in the presence of 2.5µg/mL of a cross-linking antibody, mouse anti-polyHistidine (R&D Systems, Catalog # MAB050). An E. coli-expressed rmTRANCE (aa 158 - 317) (Catalog # 462-TEC) is also available. The ED₅₀ for the E. coli-expressed rmTRANCE is 0.5 - 2 ng/mL. Molecule Information: TRANCE/TNFSF11/RANK L Long Name: TNF-related Activation-induced Cytokine Aliases: CD254; RANK L; TNFSF11 Entrez Gene IDs: 8600 (Human); 21943 (Mouse) Background: TRANCE/RANK L/TNFSF11 View TRANCE IHC images. TNF-related activation-induced cytokines (TRANCE), also called RANK Ligand (RANKL, receptor activator of NF-kB ligand), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a member of the TNF superfamily. Mouse and human TRANCE share 85% amino acid sequence identity. TRANCE is primarily expressed in T cells and T cell rich organs, such as thymus and lymph nodes.