货号：07-638

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Mre11 Antibody | 07-638 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Mre11, Mr ~85kDa View All» Molecular Weight: 85kDa View All» Immunogen: KLH-conjugated, synthetic peptide (KSTRQQPSRNVTTKNYSEVIEVDES) corresponding to amino acids 597-621 of human Mre11. View All» Isotype: IgG View All» Species Reactivity:

• Human

• Monkey
  View All» Quality Assurance: Routinely evaluated by immunoblot on nuclear extracts from HeLa cells. View All» Purification Method: Protein A purfied View All» Presentation: 70% storage buffer (0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide) and 30% glycerol View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: P49959 View All» Entrez Gene Number: BC063458 View All» Gene Symbol:
  • MRE11A

  • MRE11

  • MRE11B

  • ATLD

  • HNGS1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. View All» UniProt Summary: FUNCTION: SwissProt: P49959 # Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.COFACTOR: Manganese (By similarity).SIZE: 708 amino acids; 80593 Da SUBUNIT: Component of the MRN complex composed of two heterodimers RAD50/MRE11A associated with a single NBN. Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11A and NBN (By similarity). Interacts with DCLRE1C/Artemis.SUBCELLULAR LOCATION: Nucleus (By similarity). Note=Localizes to discrete nuclear foci after treatment with genotoxic agents (By similarity).PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.DISEASE: SwissProt: P49959 # Defects in MRE11A are a cause of ataxia telangiectasia- like disorder (ATLD) [MIM:604391]. ATLD is a disease with the same clinical feature than ataxia-telangiectasia but with a somewhat milder clinical course. & Defects in MRE11A may be a cause of breast cancer.SIMILARITY: SwissProt: P49959 ## Belongs to the MRE11/RAD32 family.MISCELLANEOUS: In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral oncoproteins, thereby preventing concatenation of viral genomes in infected cells. View All» Brand Family: Upstate View All» Product Name: Anti-Mre11 Antibody | 07-638 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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