货号：07-650

品牌：Merck Millipore

规格：

目录价：￥4657.00

市场价格：￥3958.45

会员价格：￥3725.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GFAP+1 Antibody | 07-650 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: GFAP⁺¹ View All» Molecular Weight: 50kDa View All» Immunogen: synthetic peptide corresponding to a neo-C-terminus generated as a result of alternative splicing of the human GFAP mRNA (Hol et al, 2003) View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: Routinely evaluated by immunoblot of GFAP⁺¹ protein View All» Purification Method: Serum View All» Presentation: antiserum containing 0.05% sodium azide and 30% glycerol. View All» Storage Conditions: 1 year at -20°C View All» UniProt Number: P14136 View All» Entrez Gene Number: NM_002055.2 View All» Gene Symbol:

• GFAP

• FLJ45472
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunohistochemistry
    View All» Entrez Gene Summary: This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. An additional transcript variant has been described, but its full length sequence has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: P14136 # GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.SIZE: 432 amino acids; 49880 Da SUBUNIT: Isoform 3 interacts with N-terminus of PSEN1.SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with intermediate filaments.DISEASE: SwissProt: P14136 # Defects in GFAP are a cause of Alexander disease [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course.SIMILARITY: SwissProt: P14136 ## Belongs to the intermediate filament family. View All» Brand Family: Upstate View All» Product Name: Anti-GFAP+1 Antibody | 07-650 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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