货号：07-675

品牌：Merck Millipore

规格：

目录价：￥4439.00

市场价格：￥3773.15

会员价格：￥3551.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PIKE-L/S Antibody | 07-675 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: PIKE-L and PIKE-S doublet View All» Molecular Weight: PIKE-L, Mr 150kDa, and PIKE-S doublet Mr 98kDa View All» Immunogen: 6His-tagged fusion protein corresponding to residues 268-384 of rat PIKE-L View All» Isotype: IgG View All» Species Reactivity:

• Human

• Rat
  View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from PC12 cells View All» Purification Method: Protein A purfied View All» Storage Conditions: stable for 2 years at -20°C from date of shipment View All» UniProt Number: Q99490 View All» Entrez Gene Number: NM_014770.2 View All» Gene Symbol:
  • CENTG1

  • GGAP2

  • PIKE

  • KIAA0167

  • FLJ16430

  • AGAP-2

  • AGAP2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: Q99490 # GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system.SIZE: 1192 amino acids; 124674 Da SUBUNIT: Isoform 1 interacts with EPB41L1, PLCG1, NF2, HOMER1 and HOMER2 (By similarity). Isoform 2 interacts with activated AKT1 in the presence of guanine nucleotides, and with the AP-1 complex.SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Nucleus. & Isoform 2: Cytoplasm.TISSUE SPECIFICITY: Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart.DOMAIN: SwissProt: Q99490 G domain binds GTP and has GTPase activity. & Arf-GAP domain interacts with G domain and may regulate its GTPase activity. & Although both PH domains of isoforms 1 and 2 bind phospholipids, they differently regulate subcellular location. PH domain of isoform 1 directs the protein to the nucleus, but PH domain of isoform 2 directs it to the cytosol. PH domain of isoform 2 is required for binding to AP-1.SIMILARITY: Belongs to the centaurin gamma-like family. & Contains 2 ANK repeats. & Contains 1 Arf-GAP domain. & Contains 1 Miro domain. & Contains 1 PH domain.MISCELLANEOUS: Isoform 2 seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. View All» Brand Family: Upstate View All» Product Name: Anti-PIKE-L/S Antibody | 07-675 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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