货号：07-680

品牌：Merck Millipore

规格：1EA

目录价：￥5542.65

市场价格：￥4711.25

会员价格：￥4434.12

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Histone H2B Antibody, testis variant | 07-680 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: histone H2B, testis variant View All» Molecular Weight: Mr 15kDa View All» Immunogen: KLH-conjugated, synthetic peptide spanning amino acids 7-17 (...GATISKKGFKK...) of human testis/sperm specific histone H2B View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Predicted to cross-react with rat based on sequence homology View All» Quality Assurance: routinely evaluated by immunoblot in whole cell extracts from mouse testis cells. View All» Purification Method: Antiserum View All» Storage Conditions: stable 2 years at -20°C from date of shipment View All» UniProt Number: Q96A08 View All» Entrez Gene Number: NM_170610.2 View All» Gene Symbol:
  • HIST1H2BA

  • H2BFU

  • bA317E16.3

  • STBP

  • TSH2B
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. View All» UniProt Summary: FUNCTION: SwissProt: Q96A08 # Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.SIZE: 127 amino acids; 14167 Da SUBUNIT: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Transcribed exclusively in testis, and the corresponding protein is also present in mature sperm.PTM: Monoubiquitination of Lys-122 by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II.SIMILARITY: SwissProt: Q96A08 ## Belongs to the histone H2B family. View All» Brand Family: Upstate View All» Product Name: Anti-Histone H2B Antibody, testis variant | 07-680 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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