货号：07-689

品牌：Merck Millipore

规格：200Ul

目录价：￥6588.00

市场价格：￥5599.80

会员价格：￥5270.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-EZH2 Antibody | 07-689 View All» Replaces: 07-400 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: EZH2 View All» Molecular Weight: 95-100kDa View All» Immunogen: His-tagged fusion protein corresponding to residues 1-343 of mouse enhancer of Zeste homolog 2 (EZH2) View All» Background Information: Polycomb protein group complexes are responsible for the regulation of hundreds of genes in mammals and insects. These proteins are responsible for the assembly and packaging of chromatin and for the induction of methylation on Histone H3. EZH2 (enhancer of zeste homologue 2) is a member of the polycomb group of proteins and is involved in cell cycle regulation. EZH2 represses transcription via trimethylation of histone H3 on Lys27 (H3K27) as indicated by the fact that RNAi-mediated knockdown of EZH2 resulted in a loss of H3K27 trimethylation. The expression of this protein in human tumors is aggressive for hormone refractory prostate cancer. In breast cancer EZH2 expression was increased in malignant tumors and promoted anchorage independent and invasive growth in vitro. View All» Species Reactivity:

• Human

• Mouse
  View All» Control: K562 cell lysate, C2C12 cell lysate View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from HeLa and C2C12 cells View All» Purification Method: Antiserum View All» Storage Conditions: stable for 2 years at -20°C from date of shipment View All» UniProt Number: Q15910 View All» Entrez Gene Number:
  • NM_004456.3

  • NM_152998.1
    View All» Gene Symbol:
    • EZH2

    • MGC9169

    • ENX-1
      View All» Alternate Names:
      • KMT6

      • Enx1

      • Enhancer of Zeste Homologue 2
        View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
        • Immunoprecipitation

        • Western Blotting

        • ChIP-seq
          View All» Entrez Gene Summary: This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Two transcript variants encoding distinct isoforms have been identified for this gene. View All» UniProt Summary: FUNCTION: SwissProt: Q15910 # May be involved in the regulation of gene transcription and chromatin structure.SIZE: 746 amino acids; 85363 Da SUBUNIT: Binds ATRX via the SET domain (Probable).SUBCELLULAR LOCATION: Nucleus (Probable).TISSUE SPECIFICITY: Expressed in many tissues.SIMILARITY: SwissProt: Q15910 ## Belongs to the EZ family. & Contains 1 SET domain. View All» Brand Family: Upstate View All» Product Name: Anti-EZH2 Antibody | 07-689 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Serum View All» Host: Rabbit View All»
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