金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Arg136-Arg684, with a C-terminal 6-His tag Accession #:Q02487 N-terminal Sequence Analysis:Arg136 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:62.2 kDa SDS-PAGE:85 kDa, reducing conditions Activity:Measured by the ability of the immobilized protein to support the adhesion of Caki‑2 human clear cell carcinoma epithelial cells.When 3 x 10⁴ cells/well are added to rhDesmocollin-2 coated plates (10 µg/mL, 100µL/well), approximately 40 - 60% will adhere after 90 minutes at 37° C. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: Desmocollin-2 Aliases: ARVD11; CDHF2; DG2; DSC2 Entrez Gene IDs: 1824 (Human); 13506 (Mouse); 291760 (Rat) Background: Desmocollin-2 DSC2 belongs to the cadherin family of adhesion molecules. It is a principal component of epithelial cell desmosomes and interacts homophilically as well as heterophilically with Desmoglein-2. DSC2 is the only desmocollin that is normally expressed in simple epithelia of the GI tract, although it is downregulated during colon carcinogenesis. A variety of DSC2 mutations are associated with the cardiac arrythmia disorder ARVC.