货号：07-691

品牌：Merck Millipore

规格：EA

目录价：￥3460.00

市场价格：￥2941.00

会员价格：￥2768.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MEKK3 Antibody | 07-691 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: MEKK3 View All» Molecular Weight: 70kDa View All» Immunogen: synthetic peptide corresponding to amino acids 254-268 of human mitogen-activated protein kinase kinase kinase 3 (MEKK3) View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Quality Assurance: Routinely evaluated by immunoblot with RIPA lysates from 3T3/A31 View All» Purification Method: Immunoaffinity purified View All» Storage Conditions: 1 year at -20°C from date of shipment View All» UniProt Number: Q99759 View All» Entrez Gene Number:
  • NM_002401.3

  • NM_203351.1
    View All» Gene Symbol:
    • MAP3K3

    • MAPKKK3

    • MEKK3
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. View All» UniProt Summary: FUNCTION: SwissProt: Q99759 # Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.COFACTOR: Magnesium.SIZE: 626 amino acids; 70898 Da SUBUNIT: Binds both upstream activators and downstream substrates in multimolecular complexes. Part of a complex with MAP2K3, RAC1 and CCM2. Interacts with MAP2K5 and SPAG9.SIMILARITY: SwissProt: Q99759 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. & Contains 1 OPR domain. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-MEKK3 Antibody | 07-691 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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