金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived Accession #:P35969 N-terminal Sequence Analysis:Ser27 Structure:Disulfide-linked homodimer Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:110 kDa (monomer) SDS-PAGE:150-170 kDa, reducing conditions Activity:Measured by its ability to inhibit the VEGF-dependent proliferation of HUVEC human umbilical vein endothelial cells. Conn, G. et al. (1990) Proc. Natl. Acad. Sci. USA 87:1323.The ED₅₀ for this effect is typically 10‑30ng/mL. Formulation:Lyophilized from a 0.2 µm filtered solution in MOPS, NaCl and CHAPS.See Certificate of Analysis for details. Molecule Information: VEGF R1/Flt-1 Long Name: Vascular Endothelial Growth Factor Receptor 1 Aliases: FLT1; Flt-1 Entrez Gene IDs: 2321 (Human); 14254 (Mouse) Background: VEGF R1, R3

VEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis.