货号：07-708

品牌：Merck Millipore

规格：

目录价：￥4755.00

市场价格：￥4041.75

会员价格：￥3804.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Pals1 Antibody | 07-708 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes Pals1 View All» Molecular Weight: Mr 77kDa View All» Immunogen: KLH-conjugated, synthetic peptide (C-YNANKNDDYDNE) corresponding to amino acids 450-461 of human Pals1 (palmitoylated 5 protein), also known as MAGUK p55 subfamily member 5 and stardust (Drosophila). The immunizing sequence is identical in orangutan, chimpanzee, chicken, mouse, rat, canine and fish. View All» Isotype: IgG View All» Species Reactivity:

• Canine

• Rat
  View All» Species Reactivity Note: Predicted to cross-react with human, orangutan, chimpanzee, mouse, chicken and fish based on sequence homology View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Immunoaffinity purified View All» Storage Conditions: 1 year at -20°C from date of shipment View All» UniProt Number: Q8N3R9 View All» Entrez Gene Number: NM_022474.2 View All» Gene Symbol:
  • MPP5

  • FLJ12615

  • PALS1

  • stardust
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: Members of the peripheral membrane-associated guanylate kinase (MAGUK) family function in tumor suppression and receptor clustering by forming multiprotein complexes containing distinct sets of transmembrane, cytoskeletal, and cytoplasmic signaling proteins. All MAGUKs contain a PDZ-SH3-GUK core and are divided into 4 subfamilies, DLG-like (see DLG1; MIM 601014), ZO1-like (see TJP1; MIM 601009), p55-like (see MPP1; MIM 305360), and LIN2-like (see CASK; MIM 300172), based on their size and the presence of additional domains (Tseng et al., 2001 [PubMed 11311936]). MPP5 is a member of the p55-like MAGUK subfamily.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q8N3R9 # May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of VIL2 to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity).SIZE: 675 amino acids; 77294 Da SUBUNIT: Interacts with the LIN7 proteins, CRB3 and MPDZ. Interacts with INADL, PARD6B, SC6A1 and VIL2 (By similarity). Forms a complex with CRB1 and MPP4. Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3.SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Intracytoplasmic membrane; Peripheral membrane protein. Note=Localized to the tight junctions of epithelial cells and a subset of intracellular vesicles. In the retina, detected at the outer limiting membranes (OLM), apical to the adherens junction (AJ), where it colocalizes with CRB1. Localized to the Purkinje cell body and axon.TISSUE SPECIFICITY: Expressed in the retina (at protein level).DOMAIN:SwissProt: Q8N3R9 The L27 domain 1 functions in targeting to the tight junctions by binding to INADL (By similarity). & The PDZ domain binds to the C-terminus of SC6A1 (By similarity).SIMILARITY: Belongs to the MAGUK family. & Contains 1 guanylate kinase-like domain. & Contains 2 L27 domains. & Contains 1 PDZ (DHR) domain. & Contains 1 SH3 domain. View All» Brand Family: Upstate View All» Product Name: Anti-Pals1 Antibody | 07-708 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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