货号：07-713

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-BACH1/BRIP1 Antibody | 07-713 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: BACH1/BRIP1 View All» Molecular Weight: 130kDa View All» Immunogen: KLH-conjugated, synthetic peptide corresponding to amino acids 1225-1244 (KTHEIEIKNFKPSPSKNKGM) of human BACH1/BRIP1. View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Protein A purfied View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: Q9BX63 View All» Entrez Gene Number: NM_032043.1 View All» Gene Symbol:

• BRIP1

• FANCJ

• BACH1

• FLJ90232

• MGC126521

• OF

• MGC126523
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunoprecipitation

  • Western Blotting
    View All» Entrez Gene Summary: The protein encoded by this gene is a member of the RecQ DEAH helicase family and interacts with the BRCT repeats of breast cancer, type 1 (BRCA1). The bound complex is important in the normal double-strand break repair function of breast cancer, type 1 (BRCA1). This gene may be a target of germline cancer-inducing mutations. View All» UniProt Summary: FUNCTION: SwissProt: Q9BX63 # DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.SIZE: 1249 amino acids; 140878 Da SUBUNIT: Binds directly to the BRCT domains of BRCA1.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in testis.PTM: Phosphorylated. Phosphorylation is necessary for interaction with BRCA1, and is cell-cycle regulated.DISEASE: SwissProt: Q9BX63 # Defects in BRIP1 are a cause of susceptibility to breast cancer (BC) [MIM:114480]. BC is an extremely common malignancy, affecting one in eight women during their lifetime. A positive family history has been identified as major contributor to risk of development of the disease, and this link is striking for early- onset breast cancer. & Defects in BRIP1 are the cause of Fanconi anemia complementation group J (FANCJ) [MIM:609054, 227650]. Fanconi anemia (FA) is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.SIMILARITY: SwissProt: Q9BX63 ## Belongs to the DEAD box helicase family. DEAH subfamily. & Contains 1 helicase ATP-binding domain. View All» Brand Family: Upstate View All» Product Name: Anti-BACH1/BRIP1 Antibody | 07-713 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://www.16ao.com/thread-136228.htm
    © Merck Millipore代理07-713 Anti-BACH1/BRIP1 100ug;已停产，产品报价联系微信jinshanbio