货号：07-715

品牌：Merck Millipore

规格：

目录价：￥3908.00

市场价格：￥3321.80

会员价格：￥3126.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-EGFR (Tyr1069) Antibody | 07-715 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: phospho-EGFR (Tyr1069). Tyr1069 corresponds to the position in the human (isoform a) and mouse precursor proteins. This corresponds to Tyr1044 (indicated as Tyr1045 in several publications) in the mature human and mouse protein, and to Tyr1068 in the rat and pig precursor protein. View All» Molecular Weight: 170-180kDa View All» Immunogen: KLH-conjugated, synthetic peptide corresponding to amino acids ...QR(pY)SS..., in which pY corresponds to phospho-tyrosine at residue 1069 of human epidermal growth factor receptor (EGFR) View All» Modifications: Phosphorylation View All» Species Reactivity: Human View All» Species Reactivity Note: Predicted to cross react with bovine, canine, and porcine based on sequence homology View All» Quality Assurance: Routinely evaluated by immunoblot on RIPA lysates from EGF-stimulated A431 cells View All» Purification Method: Serum View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: P00533 View All» Entrez Gene Number:

• NM_005228.3

• NM_201282.1

• NM_201283.1

• NM_201284.1
  View All» Gene Symbol:
  • EGFR

  • ERBB1

  • ERBB

  • mENA
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist.SIZE: 1210 amino acids; 134277 Da SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1.SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.TISSUE SPECIFICITY: Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. & Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.DISEASE:SwissProt: P00533 # Defects in EGFR are associated with lung cancer [MIM:211980].SIMILARITY: SwissProt: P00533 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation." View All» Brand Family: Upstate View All» Product Name: Anti-phospho-EGFR (Tyr1069) Antibody | 07-715 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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