金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived, Ser23-Arg351 Accession #:NP_033549 N-terminal Sequence Analysis:Ser23 Purity:>60%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:36.6 kDa SDS-PAGE:43 kDa, reducing conditions Activity:Measured by its ability to induce alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells. Nakamura, K. et al. (1999) Exp. Cell Res. 250:351.The ED₅₀ for this effect is 15 - 60 ng/mL. Molecule Information: Wnt-4 Long Name: Wingless-type MMTV Integration Site Family, Member 4 Entrez Gene IDs: 54361 (Human); 22417 (Mouse) Background: Wnt-4

In humans, mutations in Wnt-4 are the cause of SERKAL syndrome, a syndrome consisting of female to male sex reversal, renal, adrenal, and lung dysgenesis, and developmental defects. Mutations in Wnt-4 also result in Rokitansky-Kuster-Hauser syndrome, which is characterized by utero-vaginal atresia in otherwise phenotypically normal females with normal 46, XX karyotype.