货号：07-726

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-FANCG (Ser383) Antibody | 07-726 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: phospho-FANCG (Ser383) View All» Molecular Weight: 70kDa View All» Immunogen: KLH-conjugated, synthetic peptide corresponding to amino acids 374-385 (C-LLDSSEPRF[pS]PP) of human fanconi anemia, complementation group G (FANCG) where [pS] is phosphoserine 383. An N-terminal cysteine was added for conjugation purposes. View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Protein A purfied View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: O15287 View All» Entrez Gene Number: NM_004629.1 View All» Gene Symbol:

• FANCG

• XRCC9

• FAG
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Dot Blot

  • Western Blotting
    View All» Entrez Gene Summary: The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group G. View All» UniProt Summary: FUNCTION: SwissProt: O15287 # DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Candidate tumor suppressor gene.SIZE: 622 amino acids; 68554 Da SUBUNIT: Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients.SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=The major form is nuclear. The minor form is cytoplasmic.TISSUE SPECIFICITY: Highly expressed in testis and thymus. Found in lymphoblasts.DISEASE: SwissProt: O15287 # Defects in FANCG are a cause of Fanconi anemia (FA) [MIM:227650]. FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.SIMILARITY: SwissProt: O15287 ## Contains 4 TPR repeats. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-FANCG (Ser383) Antibody | 07-726 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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