R&D Systems代理4776-SE-010 Recombinant Human Hepsin Protein, CF (10 UG)-试剂-金山科研平台

R&D Systems代理4776-SE-010 Recombinant Human Hepsin Protein, CF (10 UG)

2025-06-28

货号：4776-SE-010

品牌：R&D Systems

规格：10ug

目录价：￥4490.00

市场价格：￥3592.00

会员价格：￥3592.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Arg45-Leu417 (Asp161Glu & Arg162Lys), with a C-terminal 10-His tag Accession #:P05981 N-terminal Sequence Analysis:Arg45 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:42 kDa SDS-PAGE:40-43 kDa, reducing conditions Activity:Measured by its ability to cleave tert-butoxycarbonyl-Gln-Arg-Arg-7-amino-4-methylcoumarin (Boc-QRR-AMC).The specific activity is >20,000 pmol/min/µg, as measured under the described conditions. Formulation:Supplied as a 0.2 µm filtered solution in Sodium Acetate and NaCl.See Certificate of Analysis for details. Molecule Information: Hepsin Aliases: HPN; TMPRSS1 Entrez Gene IDs: 3249 (Human); 15451 (Mouse); 29135 (Rat) Background: Hepsin

View Hepsin IHC images. Hepsin, also known as TMPRSS1, is a Type II membrane protein with an extracellular serine protease domain. It is most highly expressed in liver, but is also present in many other tissues, notably lung, kidney, and skeletal muscle. A soluble form of Hepsin lacking the transmembrane domain has been identified. Hepsin is capable of activating Factor VII, and may initiate blood coagulation at the cell surface. Hepsin is overexpressed in various human tumors, including prostate, and is considered to be a biomarker for prostate cancer. rhHepsin was expressed as a secreted, soluble protein lacking its cytosolic and transmembrane domains. The D161E and R162K mutations were introduced into the prosequence to improve expression of the rhHepsin.

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