货号：07-741

品牌：Merck Millipore

规格：200UL

目录价：￥5513.00

市场价格：￥4686.05

会员价格：￥4410.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-AS160 (Rab-GAP) Antibody | 07-741 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes AS160 (Rab-GAP), Mr 160 kDa. View All» Molecular Weight: Approx. 160 kDa View All» Immunogen: KLH-conjugated, synthetic peptide corresponding to amino acids 1178-1189 (C-PTNDKAKAGNKP) of rat Akt substrate of 160kDa (AS160) (Rab-GAP) with a N-terminal cysteine for conjugation purposes. View All» Isotype: IgG View All» Background Information: AS160 (Akt Substrate of 160 kDa, Akt1S1), Rab GAP (GTPase activating protein), is phosphorylated on multiple sites by Akt in response to insulin in adipocytes and contraction in muscles. AS160 is the long sought after link between the upstream insulin signaling through insulin/PI3K/Akt and GLUT4 vessicle translocation to the cell membrane. It has 6 Akt phosphorylation consensus sequences that are believed to become phosphorylated upon insulin stimulation. This phosphorylation is required for translocation of GLUT4-containing vesicles to the cell membrane1. A mutation of two or more of these phosphorylation sites results in a dramatic decrease in AS160 activity and insulin-stimulated GLUT4 redistribution at the cell membrane2. AS160 has also shown to be important for GLUT4 expcytosis2. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Canine
  View All» Species Reactivity Note: Human and mouse. Predicted to cross react with rat and dog based on sequence homology. View All» Control: MDI-treated 3T3/L1 cell lysates. View All» Quality Assurance: Routinely evaluated by Western Blot in RIPA lysates from 3T3/L1 cells differentiated into adipocytes.Western Blot Analysis: A 1:1000-1:5000 dilution of this lot detected AS160 (Rab-GAP) in RIPA lysates from 3T3/L1 cells differentiated into adipocytes by MDI treatment. This lot also detects AS160 (Rab-GAP) in HEK293 lysates. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal antiserum IgG in buffer containing 0.05% sodium azide and 30% glycerol. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: O60343 View All» Entrez Gene Number: NP_055647 View All» Gene Symbol:
  • AS160

  • DKFZp779C0666

  • KIAA0603

  • OTTHUMP00000018505

  • OTTHUMP00000040818
    View All» Alternate Names:
    • Acrg embryonic lethality minimal region ortholog

    • Akt substrate of 160 kDa

    • TBC (Tre-2, BUB2, CDC16) domain-containing protein

    • TBC1 domain family, member
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: O60343 # May act as a GTPase-activating protein for Rab family protein(s).SIZE: 1298 amino acids; 146563 Da TISSUE SPECIFICITY: Expressed in heart, skeletal muscle and in immune tissues (spleen, lymph node and leukocytes).PTM: Phosphorylated by AKT1; insulin-induced. & Insulin-stimulated phosphorylation is required for GLUT4 translocation (By similarity).DISEASE: SwissProt: O60343 # May be involved in atopic dermatitis (AD).SIMILARITY: SwissProt: O60343 ## Contains 2 PID domains. & Contains 1 Rab-GAP TBC domain. MISCELLANEOUS: Subcellular redistribution from low density microsomes to the cytosol with insulin treatment (By similarity). View All» Brand Family: Upstate View All» Product Name: Anti-AS160 (Rab-GAP) Antibody | 07-741 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Serum View All» Host: Rabbit View All»
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