货号：07-746

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Frizzled 4 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Frizzled 4 View All» Molecular Weight: 45 kDa View All» Immunogen: GST fusion protein corresponding to residues 55-225 of rat Frizzled 4 View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Application Notes: not recommended for blotting on untransfected cells View All» Quality Assurance: Routinely evaluated by immunoblot on RIPA lysates from cells that had been transfected with Frizzled 4 View All» Purification Method: Immunoaffinity purified View All» Storage Conditions: 1 year at -20°C from date of shipment View All» UniProt Number: Q9ULV1 View All» Entrez Gene Number: NM_012193.2 View All» Gene Symbol:
  • FZD4

  • FZD4S

  • FzE4

  • EVR1

  • MGC34390

  • hFz4

  • Fz-4

  • FEVR

  • GPCR
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Western Blotting
      View All» Entrez Gene Summary: This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence. View All» UniProt Summary: FUNCTION: SwissProt: Q9ULV1 # Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a critical role in retinal angiogenesis.SIZE: 537 amino acids; 59881 Da SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.TISSUE SPECIFICITY: Almost ubiquitous. Largely expressed in adult heart, skeletal muscle, ovary, and fetal kidney. Moderate amounts in adult liver, kidney, pancreas, spleen, and fetal lung, and small amounts in placenta, adult lung, prostate, testis, colon, fetal brain and liver.DOMAIN:SwissProt: Q9ULV1 Lys-Thr-X-X-X-Trp motif is involved in the activation of the Wnt/beta-catenin signaling pathway (By similarity). & The FZ domain is involved in binding with Wnt ligands (By similarity).DISEASE: SwissProt: Q9ULV1 # Defects in FZD4 are a cause of exudative vitreoretinopathy 1 (EVR1) [MIM:133780]; also known as autosomal dominant familial exudative vitreoretinopathy (FEVR) or Criswick- Schepens syndrome. FEVR is a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. This may lead to compensatory retinal neovascularization, which is thought to be induced by hypoxia from the initial avascular insult. New vessels are prone to leakage and rupture causing exudates and bleeding, followed by scarring, retinal detachment and blindness. FEVR is reported to have a penetrance of 100%, but clinical features can be highly variable, even within the same family. Patients with mild forms of the disease are asymptomatic, and their only disease-related abnormality is an arc of avascular retina in the extreme temporal periphery.SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family. & Contains 1 FZ (frizzled) domain. View All» Brand Family: Upstate View All» Product Name: Anti-Frizzled 4 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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