货号：07-750

品牌：Merck Millipore

规格：EA

目录价：￥4520.00

市场价格：￥3842.00

会员价格：￥3616.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-acetyl-Histone H3 (Lys79) Antibody | 07-750 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes acetyl-Histone H3 (Lys79), Mr 17 kDa. Does not recognize unmodified Histone H3. View All» Molecular Weight: 17 kDa View All» Epitope: Acetylated Lys79 of Histone H3 View All» Immunogen: KLH-conjugated, synthetic peptide containing the sequence (…DF[acK]TD…) where [AcK] corresponds to acetyl-lysine 79 of human histone H3. View All» Modifications: Acetylation View All» Isotype: IgG View All» Background Information: Methylation of Lysine 79 in Histone 3 acts as a marker of inactive chromatin regions. Methylation by Dot1 methylase on lysine-79 (Lys79) of Histone H3 is criticial for transcriptional silencing, and it is thought that silencing proteins such as Sir3 function by blocking Dot1 methylation. Likewise, it is predicted that acetylation of Lys79 may indicate active gene transcription. View All» Species Reactivity: Human View All» Species Reactivity Note: Broad species cross-reactivity expected due to sequence homology. View All» Application Notes: Western Blot Analysis: A 1:1000-1:2000 dilution detected acetyl-Histone H3 (Lys79) in acid extracts from HeLa cells. Signal is increased in cells treated with sodium butyrate (Catalog # 19-137), a histone deacetylase inhibitor. No detection of recombinant, unmodified human Histone H3 (Catalog # 14-494) was observed.Optimal working dilutions must be determined by the end user. View All» Control: Tested on acid extracted proteins from HeLa cells View All» Purification Method: Immunoaffinity purified View All» Presentation: Purified rabbit IgG in 70% storage buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide, 5 mg/mL BSA and 30% glycerol. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt. Avoid repeated freeze/thaw cycles.Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol-containing solutions to become frozen during storage. View All» UniProt Number: Q5KA91 View All» Entrez Gene Number: NP_003484 View All» Gene Symbol:

• H3F3A

• H3.3B

• H3F3

• MGC87783

• H3F3B

• H3.3A

• MGC87782
  View All» Alternate Names:
  • H3K79Ac

  • Histone H3 (acetyl K79)
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • ELISA
      View All» Entrez Gene Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded is a replication-independent member of the histone H3 family. View All» Brand Family: Upstate View All» Product Name: Anti-acetyl-Histone H3 (Lys79) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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