货号：07-786

品牌：Merck Millipore

规格：100UL

目录价：￥5399.00

市场价格：￥4589.15

会员价格：￥4319.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-IRSp53 Antibody | 07-786 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes IRSp53 View All» Molecular Weight: 53 kDa View All» Immunogen: Peptide corresponding to amino acids 293-380 of human IRSp53. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Serum View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: Q9UQB8 View All» Entrez Gene Number:
  • NM_006340.1

  • NM_017450.1

  • NM_017451.1
    View All» Gene Symbol:
    • BAIAP2

    • IRSP53

    • IRSp53/58

    • IRSp53

    • IRS-58

    • BAP2

    • FLAF3
      View All» Alternate Names: insulin receptor substrate p53, BAP2, BAIAP2, BAI1-associated protein 2, View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. Alternative splicing of the 3'-end of this gene results in three products of undetermined function. View All» UniProt Summary: FUNCTION: SwissProt: Q9UQB8 # Adapter protein that links membrane-bound small G- proteins to cytoplasmic effector proteins. Necessary for CDC42- mediated reorganization of the actin cytoskeleton and for RAC1- mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation.SIZE: 552 amino acids; 60868 Da SUBUNIT: Homodimer. Interacts with CDC42 and RAC1 that have been activated by GTP binding. Interacts with ATN1, BAI1, EPS8, SHANK1, SHANK2, SHANK3, WASF1 and WASF2. Interacts with ENAH after recruitment of CDC42. Interacts with TIAM1 and DIAPH1 (By similarity).SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Cell projection, filopodium. Cell projection, ruffle. Note=Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles.TISSUE SPECIFICITY: Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta.DOMAIN: "SwissProt: Q9UQB8 The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation. & The SH3 domain interacts with ATN1, BAI1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH.PTM: Phosphorylated on tyrosine residues by INSR in response to insulin treatment.SIMILARITY: Contains 1 IMD (IRSp53/MIM homology) domain. & Contains 1 SH3 domain. " View All» Brand Family: Upstate View All» Product Name: Anti-IRSp53 Antibody | 07-786 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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