金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived Accession #:P31041 N-terminal Sequence Analysis:Lys21 Structure:Disulfide-linked homodimer Purity:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:52 kDa (monomer) SDS-PAGE:60 kDa, reducing conditions Activity:Measured by its ability to inhibit IL-2 secretion by stimulated Jurkat human acute T cell leukemia cells. Freeman,G.J. etal. (1993) Science 262:909.The ED₅₀ for this effect is typically 0.3 - 1.2 µg/mL when stimulated with 1 µg/mL recombinant human B7-1 Fc Chimera in the presence of PHA. Molecule Information: CD28 Aliases: CD28 Entrez Gene IDs: 940 (Human); 12487 (Mouse) Background: CD28 CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Mouse CD28 is expressed constitutively on virtually 100% of mouse Tcells and on developing thymocytes.