货号：07-824

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-eIF4G (Ser1108) Antibody | 07-824 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes eIF4G phosphorylated on Ser1108. View All» Immunogen: KLH conjugated synthetic peptide corresponding to amino acids surrounding Ser1108 of human eIF4G. View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Immunoaffinity purified View All» UniProt Number: Q04637 View All» Entrez Gene Number:

• NM_004953.3

• NM_182917.2

• NM_198241.1

• NM_198242.1

• NM_198244.1
  View All» Gene Symbol:
  • EIF4G1

  • EIF4GI

  • EIF4G

  • eIF-4G1

  • EIF4-gamma

  • EIF4F

  • p220

  • DKFZp686A1451
    View All» Alternate Names: eukaryotic translation initiation factor 4 gamma, EIF4F View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a component of the protein complex EIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms. View All» UniProt Summary: FUNCTION: SwissProt: Q04637 # Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.SIZE: 1600 amino acids; 175535 Da SUBUNIT: eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. During rotaviral infection, rotavirus RNA-binding protein NSP3 interacts with EIF4G1 and takes the place of PABPC1. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3.PTM: Phosphorylated at multiple sites in vivo. & Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription.SIMILARITY: SwissProt: Q04637 ## Belongs to the eIF4G family. & Contains 1 MA3 domain. & Contains 1 MIF4G domain. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-eIF4G (Ser1108) Antibody | 07-824 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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