货号：07-845

品牌：Merck Millipore

规格：

目录价：￥3662.00

市场价格：￥3112.70

会员价格：￥2929.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: anti-phospho-IRS1 (Tyr1229) Antibody | 07-845 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Human IRS1 (Insulin Receptor Substrate 1) phosphorylated on Tyrosine residue 1229. Sequence highly homologous with mouse and rat, but have not been tested. View All» Molecular Weight: 165 kDa View All» Immunogen: Peptide corresponding to the amino acid region encompassing the human phospho-IRS1(Tyr1229). Sequence highly conserved in mouse and rat. View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Species Reactivity: Human View All» Species Reactivity Note: May cross-react with mouse and rat (based on sequence homology), but have not been tested. View All» Application Notes: Immunoblot Analysis: 0.5 μg/mL of this lot detected phospho-IRS1 (Tyr1229) in RIPA lysates from insulin treated IRS1 transfected CHO cells. View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Affinity Purfied View All» Presentation: 100 μL of affinity purified rabbit polyclonal IgG in buffer (PBS (without Mg²⁺ and Ca²⁺), pH 7.4 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide). View All» Storage Conditions: 2 years at -80°C. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -80°C. Avoid repeated freeze/ thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P35568 View All» Entrez Gene Number: NM_005544.1 View All» Gene Symbol:

• IRS1

• IRS-1

• HIRS-1
  View All» Alternate Names: IRS-1, Insulin Receptor Substrate-1 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: P35568 # May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).SIZE: 1242 amino acids; 131591 Da SUBUNIT: Interacts with the NPXY motif of tyrosine-phosphorylated IGF1R and INSR via the PTB domain. Binds to phosphatidylinositol 3-kinase p85 subunit via the phosphorylated YXXM motifs. Binds ROCK1. Binds to UBTF and PIK3CA in nuclear extracts (By similarity). Interacts with SOCS7.PTM: Serine phosphorylation of IRS1 is a mechanism for insulin resistance. Ser-312 phosphorylation inhibits insulin action through disruption of IRS1 interaction with the insulin receptor (By similarity). & Phosphorylation of Tyr-896 is required for GRB2-binding (By similarity).DISEASE:SwissProt: P35568 # Polymorphisms in IRS1 may be involved in the etiology of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853].SIMILARITY: SwissProt: P35568 ## Contains 1 IRS-type PTB domain. & Contains 1 PH domain. View All» Brand Family: Upstate View All» Product Name: anti-phospho-IRS1 (Tyr1229) Antibody | 07-845 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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