金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived, Ile19-Leu460 (pro) & Ala42-Leu460 (mature), both with a C-terminal 10-His tag Accession #:P33587 N-terminal Sequence Analysis:Ile19 & Ala42 Structure:Pro and Mature forms Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Endotoxin Level: Predicted Molecular Mass:49 kDa (Pro) & 48 kDa (Mature) SDS-PAGE:70 kDa, reducing conditions Activity:Measured by its ability to cleave the fluorogenic peptide substrate, Boc-beta -benzyl-DPR-AMC.The specific activity is>125pmol/min/µg, as measured under the described conditions. Formulation:Supplied as a 0.2 µm filtered solution in Sodium Acetate and NaCl.See Certificate of Analysis for details. Molecule Information: Coagulation Factor XIV/Protein C Long Name: Vitamin K-dependent Protein C Aliases: Autoprothrombin IIA; PROC; Protein C Entrez Gene IDs: 5624 (Human); 19123 (Mouse); 25268 (Rat) Background: Coagulation Factor XIV / Protein C

Coagulation Factor XIV / Protein C is a vitamin K-dependent serine protease synthesized in liver as a single-chain precursor. Present in plasma at 3 to 5 mg/L, protein C plays a key role in anticoagulation. Physiologically, the inactive forms of protein C are converted to the active form by thrombin, which releases the activation peptide. The active protein C cleaves factor VIIIa and Va to inactivate them. This anticoagulation activity can be enhanced by a presence of a cofactor such as protein S.

In hereditary thrombophilia, Coagulation Factor XIV /protein C deficiency is caused by a genetic mutation which affect protein C activity. A severe recessive form may result in massive thrombosis fatal to the patient.