货号：07-865

品牌：Merck Millipore

规格：

目录价：￥4095.00

市场价格：￥3480.75

会员价格：￥3276.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-PED/PEA-15 (Ser116) Antibody | 07-865 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes phospho-PED/PEA-15 (Ser116) View All» Molecular Weight: 15 kDa View All» Immunogen: Peptide corresponding to amino acid region encompassing the human, mouse, rat and frog phospho-PED/PEA-15 (Ser116). View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Predicted to cross-react with rat based on sequence similarity, but has not been tested. View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Affinity Purfied View All» Presentation: 100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg²⁺ and Ca²⁺), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide) and 50% glycerol. View All» Storage Conditions: Stable for 2 years at -20°C from date of shipment. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerolcontaining solutions to become frozen during storage. View All» UniProt Number: Q15121 View All» Entrez Gene Number: NM_003768.2 View All» Gene Symbol:
  • PEA15

  • PED

  • MAT1

  • HMAT1

  • MAT1H

  • HUMMAT1H

  • PEA-15
    View All» Alternate Names: PED (Phosphoprotein Enriched in Diabetes), PEA-15 (phosphoprotein enriched in astrocytes 15), RP11-536C5.8, HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes.[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: Q15121 # Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface.SIZE: 130 amino acids; 15040 Da SUBUNIT: Binds RPS6KA3, MAPK3 and MAPK1. Transient interaction with PLD1 and PLD2 (By similarity). Interacts with CASP8 and FADD.SUBCELLULAR LOCATION: Cytoplasm. Note=Associated with microtubules.TISSUE SPECIFICITY: Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose- producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls.PTM: Phosphorylated by protein kinase C and calcium-calmodulin- dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones.SIMILARITY: SwissProt: Q15121 ## Contains 1 DED (death effector) domain. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-PED/PEA-15 (Ser116) Antibody | 07-865 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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