货号：07-867

品牌：Merck Millipore

规格：EA

目录价：￥4390.00

市场价格：￥3731.50

会员价格：￥3512.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-PKA catalytic subunits α/β (Thr197) Antibody | 07-867 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes phospho- PKA α/β (Thr197) View All» Molecular Weight: ~40 kDa View All» Immunogen: Peptide corresponding to amino acid region encompassing the human, mouse, rat, cow, pig, and frog phospho-PKA α/β (Thr197). View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Species Reactivity: Mouse View All» Species Reactivity Note: Predicted to react with human and rat based on complete sequence similarity. View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Immunoaffinity purified View All» Presentation: 100 μL of affinity purified rabbit polyclonal IgG in 50% storage buffer (PBS (without Mg²⁺ and Ca²⁺), pH 7.3 containing 1.0 mg/mL BSA (IgG, protease free) and 0.05% sodium azide). View All» Storage Conditions: 2 years at -80°C. Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -80°C. Avoid repeated freeze/ thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P17612 View All» Entrez Gene Number:

• NM_002730.3

• NM_207518.1
  View All» Gene Symbol:
  • PRKACA

  • MGC102831

  • MGC48865

  • PKACA
    View All» Alternate Names: PRKACA, PRKACB, PKA C-alpha/beta, cAMP-dependent protein kinase catalytic subunit alpha/beta, protein kinase A View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. View All» UniProt Summary: FUNCTION: SwissProt: P17612 # Phosphorylates a large number of substrates in the cytoplasm and the nucleus.SIZE: 351 amino acids; 40590 Da SUBUNIT: A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Translocates into the nucleus (monomeric catalytic subunit) (By similarity). The inactive holoenzyme is found in the cytoplasm (By similarity).TISSUE SPECIFICITY: Isoform 2 is sperm specific.PTM: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively (By similarity).SIMILARITY: SwissProt: P17612 ## Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-PKA catalytic subunits α/β (Thr197) Antibody | 07-867 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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