货号：07-909

品牌：Merck Millipore

规格：1EA

目录价：￥5903.12

市场价格：￥5017.65

会员价格：￥4722.50

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Src (Tyr418) Antibody | 07-909 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes Src phosphorylated on Tyrosine residue 418. View All» Molecular Weight: 60 kDa View All» Immunogen: Peptide corresponding to amino acid region encompassing the human, mouse, rat, chicken, and frog phospho-Src (Tyr418) View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Species Reactivity:

• Chicken

• Human

• Mouse
  View All» Species Reactivity Note: Predicted to cross-react with Rat and Frog (100% homologous) based on sequence homology. View All» Application Notes: Immunoblot Analysis: 1:1000 dilutions of this lot detected phospho-Src (Tyr418) in RIPA lysate of Src transfected CEF cells. View All» Control: Chick embryo fibroblast (CEF) cells expressing human wild-type Src protein View All» Quality Assurance: Routinely evaluated by immunoblot. View All» Purification Method: Immunoaffinity purified View All» Presentation: Affinity Purified rabbit polyclonal IgG in PBS (without Mg²⁺ and Ca²⁺), pH 7.3 containing 0.5 mg/mL BSA (IgG, protease free) and 0.025% sodium azide and 50% glycerol. View All» Storage Conditions: Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P12931 View All» Entrez Gene Number:
  • NM_005417.3

  • NM_198291.1
    View All» Gene Symbol:
    • SRC

    • ASV

    • c-src

    • p60-Src

    • SRC1

    • c-SRC

    • pp60c-src
      View All» Alternate Names: c-Src, p60-Src Src kinase View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • Immunohistochemistry

      • Western Blotting
        View All» Entrez Gene Summary: This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. View All» UniProt Summary: SIZE: 536 amino acids; 59835 Da SUBUNIT: Interacts with DDEF1/ASAP1 via its SH3 domain. Interacts with CCPG1 (By similarity). Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2.PTM: Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity.SIMILARITY: SwissProt: P12931 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-Src (Tyr418) Antibody | 07-909 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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