货号：07-956

品牌：Merck Millipore

规格：EA

目录价：￥3828.00

市场价格：￥3253.80

会员价格：￥3062.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Hexim 2 Antibody | 07-956 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Hexim 2 at the N-terminus. View All» Molecular Weight: 42 kDa View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to human Hexim 2 at and around the N-terminus. View All» Background Information: Regulates transcription by acting as a general inhibitor of RNA polymerase II. Similar to HEXIM1, HEXIM2 forms a complex with p-TEFb and 7SK that prevents p-TEFb from activating transcriptional elongation. When HEXIM1 is knocked down, HEXIM2 functionally compensates for its association with P-TEFb. HEXIM2 is up-regulated by HMBA (hexamethylene bisacetamide) at protein level. View All» Species Reactivity:

• Human

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with chimpanzee based on 100% sequence homology. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.1 µg/ml of this antibody detected Hexim 2 on 10 µg of HeLa cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96MH2 View All» Entrez Gene Number: NP_653209 View All» Gene Symbol:
  • HEXIM2

  • L3
    View All» Alternate Names:
    • Hexamethylene bis-acetamide-inducible protein 2

    • MAQ1 paralog

    • hexamethylene-bis-acetamide-inducible transcript 2

    • hexamthylene bis-acetamide inducible 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. SUBUNIT STRUCTURE: Homo-oligomer and heterooligomer with HEXIM1; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Ubiquitously expressed with higher expression in testis. HEXIM1 and HEXIM2 are differentially expressed. INDUCTION: Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level). DOMAIN: The coiled-coil domain mediates oligomerization.SEQUENCE SIMILARITIES: Belongs to the HEXIM family. View All» Product Name: Anti-Hexim 2 Antibody (07-956) View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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