货号：07-958

品牌：Merck Millipore

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目录价：￥4621.00

市场价格：￥3927.85

会员价格：￥3696.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SUV39H1 Antibody | 07-958 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes SUV39H1. View All» Molecular Weight: ~ 48 kDa View All» Immunogen: GST-tagged fusion protein including amino acids 82-415 of human SUV39H1. View All» Background Information: Trimethylation of histone H3 on Lys9 (H3K9me3) is one of the most highly studied epigenetic marks. H3K9me3 functions in the repression of euchromatic genes, and in epigenetic control of heterochromatin assembly, most likely by acting as a recognition motif for the binding of chromatin-associated proteins, such as Swi6 or HP1α. The enzymes responsible for H3K9 trimethylation are SUV39H1 and SUV39H2. Suv39H1 is a nuclear protein that acts as a H3K9 specific methyltransferase (HMT). In addition to its role in gene silencing, Suv39H1 is also thought to be involved in heterochromatin organization, chromosome segregation, and mitotic progression, and the epigenetic regulation of telomere length in mammalian cells. View All» Species Reactivity: Human View All» Species Reactivity Note: Human. Does not react with mouse, rat, or bovine SUV39H1, despite significant sequence homology. View All» Non-Reactive Species:

• Bovine

• Mouse

• Rat
  View All» Application Notes: Immunoprecipitation:A previous lot of this antibody has been used to immunoprecipitate SUV39H1 from U2OS cells. View All» Control: U2OS lysate View All» Quality Assurance: Western Blot Analysis: 0.1 μg/ml dilution of this lot detected SUV39H1 on 10 μg of U2OS lysate. View All» Purification Method: Antigen affinity purified View All» Presentation: Affinity purified rabbit polyclonal in 0.1 M Tris-Glycine (pH 7.4), 15 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap. View All» UniProt Number: O43463 View All» Entrez Gene Number: NP_003164 View All» Gene Symbol:
  • EC 2.1.1.43

  • KMT1A

  • MG44

  • OTTHUMP00000024298

  • SUV39H
    View All» Alternate Names:
    • H3-K9-HMTase 1

    • Histone H3-K9 methyltransferase 1

    • Lysine N-methyltransferase 1A

    • Position-effect variegation 3-9 homolog

    • Su(var)3-9 homolog 1

    • Suppressor of variegation 3-9 homolog 1

    • histone-lysine N-methyltransferase, H3 lysine-9 specific 1

    • suppressor of variegation 3-9 (Drosophila) homolog 1

    • suppressor of variegation 3-9 homolog 1 (Drosophila)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation
        View All» Entrez Gene Summary: This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiaton, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Ref.15 Ref.19 Ref.22 Ref.23Catalytic activity S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine. Ref.7Enzyme regulation Inhibited by S-adenosyl-L-homocysteine. Ref.20SUBUNIT STRUCTURE: Interacts with H3 and H4 histones. Interacts with GFI1B, DNMT3B, CBX1, CBX4, MBD1, RUNX1, RUNX3, MYOD1, SMAD5 and RB1. Interacts with SBF1 through the SET domain. Interacts with HDAC1 and HDAC2 through the N-terminus and associates with the core histone deacetylase complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. In case of infection, interacts with HTLV-1 Tax protein, leading to abrogate Tax transactivation of HTLV-1 LTR. Ref.22 Ref.1 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12 Ref.13 Ref.16 Ref.17 Ref.18 Ref.24 Ref.25SUBCELLULAR LOCATION: Nucleus. Centromere. Note= Associates with centromeric constitutive heterochromatin. Ref.6DEVELOPMENTAL STAGE: Accumulates during mitosis at centromeres during prometaphase, but dissociates from the centromere at the meta- to anaphase transition.DOMAIN: Although the SET domain contains the active site of enzymatic activity, both pre-SET and post-SET domains are required for methyltransferase activity. The SET domain also participates to stable binding to heterochromatin. Ref.17PTM: Phosphorylated on serine residues, and to a lesser degree, on threonine residues. The phosphorylated form is stabilized by SBF1 and is less active in its transcriptional repressor function. Ref.6 Ref.21 Ref.26 Ref.27SIMILARITY: Belongs to the histone-lysine methyltransferase family. Suvar3-9 subfamily.Contains 1 chromo domain.Contains 1 post-SET domain.Contains 1 pre-SET domain.Contains 1 SET domain. View All» Product Name: Anti-SUV39H1 Antibody | 07-958 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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