货号：07-981

品牌：Merck Millipore

规格：100Ug

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Chromobox protein homolog 7 (Cbx7) Antibody | 07-981 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Cbx7 at the C-terminus. View All» Molecular Weight: ~21 kDa observed. A non-specific band at ~ 44 kDa and may be observed in some lysates. View All» Epitope: C-terminus View All» Immunogen: GST-tagged recombinant protein corresponding to the C-terminus of mouse Cbx7. View All» Background Information: Chromobox protein homologue 7 (Cbx7) is a member of the mammalian chromobox family of proteins. As a component of the Polycomb repressive complex 1 (PRC1), Cbx7, is involved in the maintenance and prolongation of cultured epithelial cell lifespan, and has been shown to function independently of BMI-1 in the repression of INK4a/ARF, a known tumor suppressor locus. Cbx7 is also able to regulate cellular lifespan through maintaining CDKN2A repression. Studies have shown Cbx7 to be up-regulated in follicular lymphoma, suggesting potential as a human oncogene. View All» Species Reactivity: Mouse View All» Application Notes: Western Blot (Snap i.d.®) Analysis: 2 µg/mL from a representative lot detected Cbx7 on 10 µg of human and mouse embryonic stem cell lysates.Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in IP. View All» Control: Mouse embryonic stem cell lysate View All» Quality Assurance: Evaluated by Western Blot in mouse embryonic stem cell lysate.Western Blot Analysis: 0.25 µg/mL of this antibody detected Cbx7 on 10 µg of mouse embryonic stem cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8VDS3 View All» Entrez Gene Number: NP_659060 View All» Gene Symbol:

• CBX7

• Cbx7
  View All» Alternate Names:
  • chromobox homolog 7

  • chromobox protein homolog 7
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation
      View All» UniProt Summary: FUNCTION: Involved in maintaining the transcriptionally repressive state of genes. Modifies chromatin, rendering it heritably changed in its expressibility (By similarity). Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity.SUBUNIT STRUCTURE: Component of the chromatin-associated polycomb complex (PcG). Interacts with RING2 (By similarity). Interacts with RING1, but not with BMI1, EED or EZH2. SUBCELLULAR LOCATION: Nucleus DEVELOPMENTAL STAGE: In embryonic fibroblast cultured in vitro, expression gradually decreases with passage number and totally disappears in senescent cells.SEQUENCE SIMILARITIES: Contains 1 chromo domain. View All» Product Name: Anti-Chromobox protein homolog 7 (Cbx7) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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