货号：08-144

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: SUMO3 Protein View All» Trade Name: Upstate (Millipore) View All» Qty/Pk: 100 µg View All» Application Notes: Mature SUMO-3 suitable for in vitro SUMOylation using the SUMO Activating Enzyme Complex (Cat. no. 14-858) and SUMO conjugating enzyme UbcH9 (Cat. no. 14-815). In The presence of these enzymes with ATP, Mg2+, and DTT, mature SUMO-3 may be conjugated to soluble proteins. The protein is N-terminally His6-tagged within a leader sequence. Typical in vitro concentration for non-rate limiting conjugate formation is 200μM to 1mM depending upon conditions. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: SUMO proteins, such as SUMO3, and ubiquitin (see MIM 191339) posttranslationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (Su and Li, 2002 [PubMed 12383504]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P55854 # Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.SIZE: 103 amino acids; 11637 Da SUBUNIT: Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins (By similarity).SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Expressed predominantly in liver.PTM: Polymeric chains can be formed through Lys-11 cross-linking. & Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.SIMILARITY: SwissProt: P55854 ## Belongs to the ubiquitin family. SUMO subfamily. & Contains 1 ubiquitin-like domain. View All» Species: Human View All» Molecular Weight: 15 kDa View All» Brand Family: Upstate View All» Presentation: 100 µg of concentration 1.0 mg/mL in 20mM HEPES, pH8.0, 50mM NaCl, 1mM DTT. View All» Storage Conditions: Stable for 1 year at -80°C from date of shipment for up to 12 months. Avoid multiple freeze/thaw cycles. After initial defrost, aliquot into individual tubes and refreeze at -80ºC. View All» Gene Symbol:

• SUMO3

• SUMO-2

• SMT3H1

• SMT3A

• SUMO-3
  View All» Product Name: SUMO3 Protein View All» Concentration: 1.0 mg/mL View All» UniProt Number: P55854 View All» Entrez Gene Number: NM_006936.2 View All» Purity: ≥95% View All»
  © 金山科研平台是专业的授权总代理区域代理经销平台。
  © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
  © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
  © 本文地址：https://www.16ao.com/thread-136560.htm
  © Merck Millipore代理08-144 SUMO3 (His6-tagged, human, recombinant);已停产，产品报价联系微信jinshanbio