货号：09-066

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ASPM Antibody | 09-066 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes ASPM. View All» Molecular Weight: 218, 95, 75 kDa Observed UniProtKB/Swiss-Prot entry Q8IZT6 describes 2 isoforms produced by alternative splicing: Isoform 1 at 409.800kDa and Isoform 2 at 217.794kDa. Multiple other isoforms in ref: Human Molecular Genetics, 2005, Vol. 14, No. 15 2155–2165. View All» Epitope: N/A View All» Immunogen: KLH-conjugated linear peptide corresponding to human ASPM. View All» Background Information: The ASPM gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts (Bond et al., 2002 [PubMed 12355089]). The mouse gene ASPM is expressed specifically in the primary sites of prenatal cerebral cortical neurogenesis. View All» Species Reactivity:

• Human

• Rat

• Chimpanzee

• Primate
  View All» Species Reactivity Note: Reacts with human. Predicted to react with chimpanzee and primate based on sequence homology. View All» Application Notes: ELISA: Tested in direct ELISA against the ASPM immunogen. View All» Control: Human ductal carcinoma tissue View All» Quality Assurance: Immunohistochemistry Analysis: 1:300 dilution of this antibody detected ASPM in human ductal carcinoma tissue. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit serum in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8IZT6 View All» Entrez Gene Number: NP_060606 View All» Gene Symbol:
  • ASPM

  • ASP

  • Calmbp1

  • MCPH5
    View All» Alternate Names:
    • Abnormal spindle protein homolog

    • Asp homolog

    • asp (abnormal spindle) homolog, microcephaly associated (Drosophila)

    • asp (abnormal spindle)-like, microcephaly associated

    • asp (abnormal spindle)-like, microcephaly associated (Drosophila)

    • microcephaly, primary autosomal recessive 5
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • ELISA
        View All» Entrez Gene Summary: The ASPM gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts (Bond et al., 2002 [PubMed 12355089]). The mouse gene ASPM is expressed specifically in the primary sites of prenatal cerebral cortical neurogenesis. View All» UniProt Summary: FUNCTION: Probable role in mitotic spindle regulation and coordination of mitotic processes By similarity. May have a preferential role in regulating neurogenesis.SUBCELLULAR LOCATION: Cytoplasm by similarity. Nucleus By similarity. Note: The nuclear-cytoplasmic distribution could be regulated by the availability of calmodulin by similarity.INVOLVEMENT IN DISEASE: Defects in ASPM are the cause of microcephaly primary type 5 (MCPH5) [MIM:608716]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait. SEQUENCE SIMILARITIES: Contains 2 CH (calponin-homology) domains.Contains 39 IQ domains. View All» Product Name: Anti-ASPM View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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