货号：09-100

品牌：Merck Millipore

规格：EA

目录价：￥3348.00

市场价格：￥2845.80

会员价格：￥2678.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RBL2 Antibody | 09-100 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes RBL2 at and around the C-terminus. View All» Molecular Weight: 130 kDa View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated linear protein corresponding to human RBL2 at and around the C-terminus. View All» Background Information: RBL2, retinoblastoma-like protein 2 also referred to as a pocket protein, belongs to the RB family of tumor suppressors, as does another pocket protein p107. These pocket proteins are involved in cell proliferation, differentiation, and transformation. They also share a significant amount of sequence homology. RBL2 is an important regulator of entry in cell division and may act as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. View All» Species Reactivity: Human View All» Species Reactivity Note: Proven to react with human. Predicted to react with rat, horse, chimpanzee, ape, and dog based on sequence homology. Mouse (95%). View All» Control: Raji cell lysate View All» Quality Assurance: Evaluated by Western Blot in raji cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected RBL2 on 10 µg of raji cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q08999 View All» Entrez Gene Number: NP_005602 View All» Gene Symbol:

• RBL2

• P130

• PRB2

• RB2

• RBR-2

• Rb2

• p130
  View All» Alternate Names:
  • 130 kDa retinoblastoma-associated protein

  • retinoblastoma-like 2 (p130)
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.SIZE: 1139 amino acids; 128367 Da SUBUNIT: Interacts with AATF. Interacts with SUV420H1 and SUV420H2 (By similarity). Interacts with RINT1.SUBCELLULAR LOCATION: Nucleus.PTM: During G0 and early G1 phase of the cell cycle, phosphorylated on Ser-639 and on 5 sites within the domain B. Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis.SIMILARITY: Belongs to the retinoblastoma protein (RB) family.MISCELLANEOUS: G0-restricted expression. View All» Product Name: Anti-RBL2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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