货号：09-126

品牌：Merck Millipore

规格：100Ug

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tribbles-1 Antibody | 09-126 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Tribbles-1 View All» Molecular Weight: 41 kDa View All» Epitope: N-terminal View All» Immunogen: KLH-conjugated sythetic linear peptide directed against a region of the N-terminal portion of Tribbles-1. View All» Isotype: IgG View All» Background Information: The Tribbles family of proteins are kinase-like proteins that contain a kinase-like domain, but lack either a catalytic domain or a protein-protein interaction domain (2). They are believed to regulate signal processing for various pathways including MAPK, Akt, and NFkB that are involved in various aspects of development, diabetes, and cancer (1,2,3). Their involvement has been reported to regulate a number of pathways that include mitosis, cell activation, and apoptosis. They are are a family made up of three family members. Tribbles-1 (TRIB1, SKIP1, G-protein-coupled receptor induced protein, and phosphoprotein regulated by mitogenic pathways) is a modulator of MAPK action. It has been shown to directly interact with the upstream kinases MEK1 and MKK4 of Erk and JNK, respectively(1). Tribble-2 (Trib2, TRB2) has been shown to interact with Akt(2). Tribbles-3 (TRIB3, TRB3. NIPK, SKIP3) has been shown to interact with Akt and the transcription factors ATF4 and NFkB p65 (RelA). It is interaction with RelA is thought to be negative regulation. Interestingly, it has been reported to regulate Akt activation via insulin(3). View All» Species Reactivity: Human View All» Control: HeLa View All» Quality Assurance: routinely evaluated by western blot on lysate from HeLa cells View All» Purification Method: Affinity Purfied View All» Presentation: 100 μg in 100μL of affinity purified rabbit serum in storage buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: 1 year at -20°C View All» UniProt Number: Q96RU8 View All» Entrez Gene Number: NP_079471 View All» Gene Symbol:

• TRIB1

• TRB1

• SKIP1

• C8FW

• GIG2
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunohistochemistry

  • Western Blotting
    View All» Brand Family: Upstate View All» Product Name: Anti-Tribbles-1 Antibody | 09-126 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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