金山科研平台，产品价格货期咨询微信：jinshanbio Source:E. coli-derived, Ala24-Ala93 Accession #:P16619.1 N-terminal Sequence Analysis:Ala24 Purity:>97%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:7.8 kDa Activity:Measured by its ability to chemoattract 2-day cultured human monocytes.The ED₅₀ for this effect is typically 1‑5ng/mL.Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CCR5.The ED₅₀ for this effect is typically 0.1‑0.4ng/mL. Molecule Information: CCL3L1/MIP-1 alpha Isoform LD78 beta Aliases: G0S19-2; LD78 beta; SCYA3L1 Entrez Gene IDs: 6349 (Human) Background: CCL3/MIP-1 alpha

The two human MIP-1 alpha genes arise by duplication/mutation. They code for MIP-1 alpha isoforms CCL3/LD78a and CCL3L1/LD78b, which share 94% amino acid sequence homology. Whereas the human CCL3/LD78a is a single-copy gene, the human CCL3L1/LD78b gene copy number varies within the population. Human CCL3L1/LD78b binds and signals through chemokine receptors CCR1, CCR5. When compared to CCL3/LD78a, CCL3L1/LD78b has higher binding affinity to CCR5, which also functions as a coreceptor for HIV-1 entry. The copy number of CCL3L1 is one of several genetic determinants of HIV-1 susceptibility.