货号：09-157

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ALK4 Antibody | 09-157 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes ALK4 View All» Molecular Weight: 57 kDa View All» Immunogen: Synthetic peptide designed against the N-terminal region of human ALK4 View All» Background Information: ALK4 (ACVR1B activin A receptor, type IB; ACVRLK4) is a transmembrane type IB receptor serine kinase for activin or activin-like ligands. Activins, are dimeric factors that belong to the TGF-superfamily of signaling proteins. Activins signal through the hetrodimeric complex that includes two type I (I and IB) and two type II (II and IIB) receptors. They type I receptors (i.e. ALK4) contains a Ser/Thr kinase domain in its cytoplasmic domain that is essential for signaling, while the type II are receptors are essential for ligand binding (Harrison, 2004 & Gray, 2000). Receptor activation involves ligand binding to the promiscuous type II receptor that is known to bind to many ligands. This leads to the recruitment of ALK4 and the formation of a stable heterodimer that results in the phosphorylation and activation of ALK4 (Harrison, 2004 & Gray, 2000). View All» Species Reactivity:

• Mouse

• Rat
  View All» Quality Assurance: Routinely evaluated by western blot on either mouse or rat brain lysate View All» Purification Method: Affinity purified using immunogen View All» Presentation: Affinity purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide with 50% glycerol. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P36896 View All» Entrez Gene Number: NP_004293 View All» Gene Symbol:
  • Activin receptor-like kinase 4

  • activin A receptor, type IB

  • activin A receptor, type II-like kinase 4

  • activin A type IB receptor

  • Activin receptor-like kinase 4

  • ACTR-IB

  • ACVRLK4

  • ALK-4
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. [provided by RefSeq] View All» UniProt Summary: Function: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators.Size: 505 amino acids; 56,807 DaSubunit Structure: Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3Subcellular Location: Membrane; Single-pass type I membrane protein. View All» Brand Family: Upstate View All» Product Name: Anti-ALK4 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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