货号：09-158

品牌：Merck Millipore

规格：200UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ALK7 Antibody | 09-158 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes ALK4 View All» Molecular Weight: 55 kDa View All» Immunogen: Synthetic peptide designed against the N-terminal region of human ALK7 View All» Background Information: ALK7 (ACVR1C activin A receptor, type IC; ACVRLK4) is a transmembrane type IC receptor serine kinase for activin or activin-like ligands. Activins, are dimeric factors that belong to the TGF-superfamily of signaling proteins. Activins signal through the hetrodimeric complex that includes two type I (I and IB) and two type II (II and IIB) receptors. The type I receptors (i.e. ALK7) contains a Ser/Thr kinase domain in its cytoplasmic domain that is essential for signaling, while the type II are receptors are essential for ligand binding (Harrison, 2004 & Gray, 2000). Receptor activation involves ligand binding to the promiscuous type II receptor that is known to bind to many ligands. This leads to the recruitment of ALK7 and the formation of a stable heterodimer that results in the phosphorylation and activation of ALK7. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Quality Assurance: Routinely evaluated by western blot on either human or rat brain lysate View All» Purification Method: Affinity purified using immunogen View All» Presentation: Affinity purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q8NER5 View All» Entrez Gene Number: NP_660302 View All» Gene Symbol:
  • Activin receptor-like kinase 7

  • Activin receptor type-1C precursor

  • activin A receptor, type IC

  • ACTR-IC

  • ACVRLK7

  • ALK-7

  • ALK7

  • EC 2.7.11.30
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM] View All» UniProt Summary: Function: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.Size: 493 amino acids; 54871 DaSubunit Structure: Binds the type 2 receptor protein ACVR2A Subcellular Location: Membrane; Single-pass type I membrane protein.Sequence Similarities: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. View All» Brand Family: Upstate View All» Product Name: Anti-ALK7; 200μL View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 μL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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