货号：09-195

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RalGDS Antibody | 09-195 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Detects RalGDS View All» Epitope: Between RasGEF & RA View All» Immunogen: KLH conjugated synthetic peptide corresponding to the area between the RasGEF domain and the RA motif. View All» Isotype: IgG View All» Background Information: RalGDS is a known Ras effector protein. It is a guanine exchange factor (GEF) that contains a Ras-GEF domain in its N-terminal domain. RalGDS is one of the GEFs, along with Rlf, Rgl, Rgl3, that are downstream effectors of Ras proteins. They act aids in the dissociation of GDP for both the small GTPase proteins RalA and RalB, thus allowing GTP binding and subsequent activation. In addition to binding to and activating the Ral G-proteins, it has also been shown to contribute to the activation of Akt by growth factors by enabling PDK1 to interact with Akt thus allowing its phosphorylation on Thr308 (Hao, 2008). View All» Species Reactivity: Human View All» Species Reactivity Note: Human. Other species have not been tested. View All» Control: COLO-587 cell lysate View All» Quality Assurance: Western Blot Analysis: This antibody detected RalGDS at 1:1,000 dilution in COLO-587 cell lysate resolved via SDS-PAGE and transferred to PVDF. View All» Purification Method: Purified View All» Presentation: Purified rabbit polyclonal in PBS with 0.1% NaN3 in 50% glycerol. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. View All» UniProt Number: Q12967 View All» Entrez Gene Number: NP_006257 View All» Gene Symbol:

• FLJ20922

• KIAA1308

• OTTHUMP00000022458

• OTTHUMP00000022460

• RGF

• RalGDS

• RalGEF
  View All» Alternate Names: ral guanine nucleotide dissociation stimulator View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap.SUBUNIT: Structure Interacts with RIT1 and RIT2 By similarity.Domain The Ras-associating domain interacts with Ras.SIMILARITY: Contains 1 N-terminal Ras-GEF domain.Contains 1 Ras-associating domain.Contains 1 Ras-GEF domain. View All» Product Name: Anti-RalGDS View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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