货号：09-268

品牌：Merck Millipore

规格：100Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TKS5 (SH3 #4) Antibody | 09-268 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: 130-150 kDa. Uncharacterized bands(s) may be observed in some cell lysates. View All» Epitope: 833-892 aa View All» Immunogen: Recombinant Protein, aa: 833-892 View All» Background Information: Tks5 (previously known as Fish), is a large scaffolding protein with one amino-terminal PX domain and five SH3 domains. It is cytoplasmic in normal fibroblasts. In Src-transformed cells, Tks5 localizes to podosomes. The coexpression of Tks5 and constitutively active Src in epithelial cancer cells resulted in the appearance of podosomes/invadopodia. Cells with reduced Tks5 expression are poorly invasive through matrigel. Tks5 is expressed and localized to podosomes/invadopodia in some invasive human cancer cell lines and tumor tissue, particularly breast cancers and melanomas. Thus, Tks5 appears to be required for podosome/invadopodia formation and for invasion of some cancer cells. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Reacts with mouse and human. View All» Control: Mouse 3T3-Src(Y527F) cells View All» Quality Assurance: Evaluated by immunocytochemistry on mouse 3T3-Src(Y527F) cells. View All» Purification Method: Protein A purfied View All» Presentation: Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. View All» UniProt Number: O89032 View All» Entrez Gene Number: NM_014631.2 View All» Gene Symbol:
  • FISH

  • KIAA0418

  • SH3MD1
    View All» Alternate Names:
    • Adaptor protein TKS5

    • Five SH3 domain-containing protein

    • SH3 and PX domains 2A

    • SH3 multiple domains 1

    • SH3 multiple domains protein 1

    • five SH3 domains
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunocytochemistry View All» UniProt Summary: FUNCTION:Required for podosome formation, degradation of the extracellular matrix, and for the invasiveness of some cancer cells. Binds phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2). In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide By similarity.SUBUNIT: Interacts with ADAM12, ADAM15 and ADAM19 By similarity.LOCATION: Cytoplasm. Cell projection › podosomeBy similarity. Note= Cytoplasmic in normal cells and localizes to podosomes in Src-transformed cells By similarity.Tissue specificity Widely expressed. Not found in the spleen and testis. Ref.1Domain The PX domain is required for podosome localization, and for binding phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,4-biphosphate (PtdIns(3,4)P2) By similarity.The fifth SH3 domain mediates binding with ADAM12, ADAM15 and ADAM19 By similarity.PTM: Tyrosine phosphorylated by SRC. Phosphorylation plays a regulatory role in the protein localization. The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the perimembrane region. Phosphorylated on serine upon DNA damage, probably by ATM or ATR By similarity.SIMILARITY: Belongs to the SH3PXD2 family.Contains 1 PX (phox homology) domain.Contains 5 SH3 domains. View All» Product Name: Anti-TKS5 (SH3 #4) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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