R&D Systems代理5170-CL-050 Recombinant Human CLEC3B/Tetranectin Protein, CF (50 UG)-试剂-金山科研平台

R&D Systems代理5170-CL-050 Recombinant Human CLEC3B/Tetranectin Protein, CF (50 UG)

2025-06-27

货号：5170-CL-050

品牌：R&D Systems

规格：50ug

目录价：￥4490.00

市场价格：￥3592.00

会员价格：￥3592.00

到货时间：3~4周

金山科研平台，产品价格货期咨询微信：jinshanbio Source:Mouse myeloma cell line, NS0-derived, Glu22-Val202, with a C-terminal 6-His tag Accession #:P05452 N-terminal Sequence Analysis:Glu22 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:21.0kDa (monomer) SDS-PAGE:25 kDa, reducing conditions Activity:Measured by its binding ability in a functional ELISA.

When rhHGF(R&D Systems, Catalog # 294-HGN) is immobilized at 5 µg/mL, the concentrationof rhCLEC3B that produces 50% of the optimal binding response is found to be approximately1 -5µg/mL.

Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: CLEC3B/Tetranectin Long Name: C-type Lectin-like Receptor 3B Aliases: TETN; Tetranectin; TNA Entrez Gene IDs: 7123 (Human); 21922 (Mouse) Background: CLEC3B CLEC3B (C-type lectin domain family 3 member B), also known as Tetranectin, is a 17 kDa O-glycosylated member of the C-type lectin superfamily. Mature human CLEC3B consists of an alpha-helical coiled-coil region followed by one C-type lectin domain (CTLD). It shares 81% amino acid sequence identity with mouse and rat CLEC3B. CLEC3B associates into non-covalent homotrimers, although it was named Tetranectin based on the proposal that it formed tetramers. CLEC3B is secreted by endocrine, epithelial, endothelial, and mesenchymal cells including several hematopoietic cell types. It shows binding selectivity for heparan sulfate, fucoidan, and chondroitin sulfates A, B, and C. CLEC3B binds the Kringle domain-containing proteins Plasminogen, tPA, and HGF, and it enhances the tPA-mediated activation of Plasminogen. It also reduces the ability of Angiostatin (a Plasminogen fragment) to inhibit vascular endothelial cell proliferation. In mouse, CLEC3B is involved in the development and repair of muscle, spine, and skin. CLEC3B is upregulated in stromal cells surrounding various tumors but not in the tumor cells themselves. It is concentrated in the extracellular matrix at the leading edge of malignant tumors, a pattern that overlaps that of Plasminogen.

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