货号：09-356

品牌：Merck Millipore

规格：EA

目录价：￥4550.00

市场价格：￥3867.50

会员价格：￥3640.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-HMG-CoA Reductase (Ser872) Antibody | 09-356 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes HMG-CoA Reductase when phosphorylated on Ser872(H) View All» Molecular Weight: 98 kDa View All» Immunogen: Synthetic peptide encompassing and including amino acids phosphorylated on Ser872 in human HMG-CoA Reductas View All» Modifications: Phosphorylation View All» Background Information: HMG-CoA reductase (HMGCR) is the rate-limiting enzyme in cholesterol biosynthesis. HMGCR it is the target for the hypolipidic agents statins. Statins are a class of cholesterol-lowering drugs that act through low density lipoproteins (LDL) to lower cholesterol. Inhibition of HMGCR stimulates the LDL receptors, which results in increased clearance of LDL from the bloodstream and a decrease in blood cholesterol levels. HMG-CoA reductase is also implicated in the regulation of receptors for LDL. HMGCR is suppressed by the cholesterol that is a product of the degradation of LDL by the LDL receptor. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Predicted to cross-react with rat View All» Quality Assurance: Routinely evaluated by western blot on untreated and calyculin-treated HeLa cell lysate View All» Purification Method: Double affinity purification over both non-phospho-peptide column followed by phopshorylated peptide column. View All» Presentation: Purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide in 50% glycerol. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P04035 View All» Entrez Gene Number: NP_000850 View All» Gene Symbol: EC 1.1.1.34 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. View All» UniProt Summary: FUNCTION: SwissProt: P04035 # This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis.SIZE: 888 amino acids; 97476 DaSUBUNIT: Homodimer.SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Peroxisome membrane; Multi-pass membrane protein.SIMILARITY:SwissProt: P04035 ## Belongs to the HMG-CoA reductase family. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-HMG-CoA Reductase (Ser872) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Affinity Purified View All» Host: Rabbit View All»
  © 金山科研平台是专业的授权总代理区域代理经销平台。
  © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
  © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
  © 本文地址：https://www.16ao.com/thread-136763.htm
  © Merck Millipore代理09-356 Anti-phospho-HMG-COA REDUCT (S872)，产品报价联系微信jinshanbio