货号：09-466

品牌：Merck Millipore

规格：100UL

目录价：￥4967.00

市场价格：￥4221.95

会员价格：￥3973.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-CrkL (Tyr207) Antibody | 09-466 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes CrkL only when phosphorylated on Tyr207. View All» Molecular Weight: 39 kDa View All» Immunogen: KLH synthetic peptide including and encompassing Tyr 207 of human CrkL. View All» Modifications: Phosphorylation View All» Background Information: CRKL belongs to a family of adaptor proteins containing SH2/SH3 domains that couple to effector proteins including p130CAS, SOS, Abl, and Arg. CRKL plays a role in the mediation of Integrin- and Rac-dependent cell migration and in Ras-dependent activation of JNK. The protein is also involved in T-cell activation. Phosphorylation of CrkL on Tyr207 is known to be correlated with its inhibition. View All» Species Reactivity:

• Human

• Rat

• Mouse
  View All» Control: K562 View All» Quality Assurance: Routinely evaluated by western blot on K563 cell lysates. View All» Presentation: Purified rabbit polyclonal IgG in storage buffer containing PBS with 0.05% sodium azide in 50% glycerol. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P46109 View All» Entrez Gene Number: NP_005198 View All» Gene Symbol:
  • v-crk avian sarcoma virus CT10 oncogene homolog-like

  • v-crk sarcoma virus CT10 oncogene homolog (avian)-like

  • Crk Like
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: NP_005198.1 View All» UniProt Summary: FUNCTION: May mediate the transduction of intracellular signals.SIZE: 303 amino acids; 33777 Da SUBUNIT STRUCTURE:Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB and IRS4.SIMILARITY: Contains 1 SH2 domain.Contains 2 SH3 domains. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-CrkL (Tyr207) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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