货号：09-471

品牌：Merck Millipore

规格：

目录价：￥3475.00

市场价格：￥2953.75

会员价格：￥2780.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-CLASP1 (Ser600) Antibody | 09-471 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes CLIP-associating protein 1 when phosphorylated at Ser600. View All» Molecular Weight: ~ 169 kDa View All» Epitope: Ser600 View All» Immunogen: KLH-conjugated linear peptide corresponding to amino acids including and surrounding phosphorylated Ser600 of human CLASP1. View All» Modifications: Phosphorylation View All» Background Information: CLASP1 (Cytoplasmic linker associated protein 1) is part of an evolutionarily conserved class of proteins known as microtubule plus-end-tracking proteins (+TIPs). This class of proteins is associated with the growing microtubule ends during mitosis. In mammals, two homologs of CLASP have been identified; CLASP1 and CLASP2. They are involved in the organizing the orientation of microtubule networks during both interphase and mitosis. CLASP1 is expressed in the outer portion of the kinetochore corona during early prometaphase and continuing through to anaphase. CLASP1 is necessary for the normal alignment and segregation of chromosomes and to regulate the dynamics of spindle microtubules. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Bovine

• Horse

• Chicken

• Xenopus
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse, rat, bovine, equine, chicken, and xenopus based on 100% sequence homology. View All» Application Notes: Western Blot Analysis: A previous lot was used by an independent laboratory in WB. (Mimori-Kiyosue, Y., et al. (2005). JCB. 168(1):141-153.) View All» Control: Modified and non modified peptides of phosphorylated and non-phosphorylated CLASP1 protein. View All» Quality Assurance: Evaluated by Dot Blot in modified and non modified peptides of phosphorylated and non-phosphorlyated CLASP1 protein.Dot Blot Analysis: 1 µg/mL of this antibody detected CLASP1 in modified and non modified peptides of phosphorylated and non-phosphorylated CLASP1 protein. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q7Z460 View All» Entrez Gene Number: NP_056097 View All» Gene Symbol:
  • CLASP1

  • MAST1

  • hOrbit1
    View All» Alternate Names:
    • CLIP-associating protein 1

    • Cytoplasmic linker-associated protein 1

    • Multiple asters homolog 1

    • cytoplasmic linker associated protein 1

    • multiple asters 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Dot Blot
        View All» Entrez Gene Summary: CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. SUBUNIT STRUCTURE: Interacts with CLIP2, ERC1, MAPRE1, MAPRE3, microtubules, PHLDB2 and RSN. The interaction with ERC1 may be mediated by PHLDB2. SUBCELLULAR LOCATION: Cytoplasm › cytoskeleton. Cytoplasm › cytoskeleton › centrosome. Kinetochore. Cytoplasm › cytoskeleton › spindle. Note: Localizes to microtubule plus ends. Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.SEQUENCE SIMILARITIES: Belongs to the CLASP family.Contains 7 HEAT repeats.SEQUENCE CAUTION: The sequence AAX88872.1 differs from that shown. Reason: Erroneous gene model prediction. View All» Product Name: Anti-phospho-CLASP1 (Ser600) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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