货号：09-478

品牌：Merck Millipore

规格：

目录价：￥3433.00

市场价格：￥2918.05

会员价格：￥2746.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-LKB1 (Ser307) Antibody | 09-478 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes LKB1 when phosphorylated at Ser307. View All» Molecular Weight: ~ 49 kDa View All» Epitope: Phosphorylated Ser307 View All» Immunogen: KLH-conjugated linear peptide corresponding to amino acids including and surrounding phosphorylated Ser307 of human LKB1. View All» Modifications: Phosphorylation View All» Background Information: LKB1 is a serine-threonine protein kinase and member of the calcium calmodulin family. LKB1 acts as a tumor suppressor and plays an important role in the regulation of many cellular processes. It is expressed in all tissues including pancreatic, liver, testicular, cardiac, and skeletal muscle tissue. Mutations in LKB1 result from unregulated cell growth and tumor formation that are associated with Peutz-Jehgers syndrome. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Bovine

• Horse
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse, rat, bovine, and equine based on 100% sequence homology. View All» Application Notes: Western Blot Analysis: A previous lot was used by an independent laboratory in WB. (Xie, Z., et al. (2009). Molecular and Cellular Biology. 29(13):3582-3596.) View All» Control: Modified and non-modified peptides of phosphorylated and non-phosphorlyated LKB1 protein View All» Quality Assurance: Evaluated by Dot Blot in modified and non-modified peptides of phosphorylated and non-phosphorlyated LKB1 protein.Dot Blot Analysis: 1 µg/mL of this antibody detected LKB1 in modified and non-modified peptides of phosphorylated and non-phosphorlyated LKB1 protein. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q15831 View All» Entrez Gene Number: NP_000446 View All» Gene Symbol:
  • STK11

  • LKB1

  • PJS
    View All» Alternate Names:
    • Renal carcinoma antigen NY-REN-19

    • Serine/threonine-protein kinase LKB1

    • polarization-related protein LKB1

    • serine/threonine kinase 11

    • serine/threonine kinase 11 (Peutz-Jeghers syndrome)

    • serine/threonine protein kinase 11
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Dot Blot
        View All» Entrez Gene Summary: This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.COFACTOR: Magnesium or Manganese.ENZYME REGULATION: Activated by binding of a complex consisting of CAB39 and STRAD or CAB39 and ALS2CR2.SUBUNIT STRUCTURE: Found in a ternary complex composed of SMAD4, STK11 and STK11IP. Interacts with SMAD4 and STK11IP. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Relocates to the cytoplasm when bound to CAB39 and STRAD or CAB39 and ALS2CR2. TISSUE SPECIFICITY: Ubiquitously expressed. Strongest expression in testis and fetal liver.PTM: Phosphorylated by a cAMP-dependent protein kinase By similarity. INVOLVEMENT IN DISEASE: Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) [MIM:175200]. PJS is a rare hereditary disease in which there is predisposition to benign and malignant tumors of many organ systems. PJS is an autosomal dominant disorder characterized by melanocytic macules of the lips, multiple gastrointestinal hamartomatous polyps and an increased risk for various neoplasms, including gastrointestinal cancer. Defects in STK11 have been associated with testicular tumors [MIM:273300]. It includes germ cell tumor (GCT) or testicular germ cell tumor (TGCT).SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily.Contains 1 protein kinase domain. View All» Product Name: Anti-phospho-LKB1 (Ser307) View All» Concentration: 0.19 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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