金山科研平台，产品价格货期咨询微信：jinshanbio Source:Chinese Hamster Ovary cell line, CHO-derived, Val20-Pro432 & Asp31-Pro432 both with a C-terminal 6-His tag Accession #:P12804 N-terminal Sequence Analysis:Val20 & Asp31 Structure:Disulfide-linked homotetramer Purity:>90%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:47.7 kDa (monomer) SDS-PAGE:60-80 kDa, reducing conditions Activity:Measured by its ability to inhibit anti-CD3-induced proliferation of mouse splenic T lymphocytes. Chan, C.W. et al. (2003) J. Immunol. 170:4036.The soluble rmFGL2 inhibited the proliferation with a typical ED₅₀ value of 1 - 4 µg/mL. Formulation:Lyophilized from a 0.2 µm filtered solution in PBS.See Certificate of Analysis for details. Molecule Information: FGL2 Long Name: Fibrinogen-like 2 Aliases: Fibroleukin; T49 Entrez Gene IDs: 10875 (Human); 14190 (Mouse); 84586 (Rat) Background: FGL2 FGL2 (fibrinogen-like protein 2), also called fibroleukin, is a 64-70 kDa secreted glycoprotein of the Fibrinogen-like superfamily. In the presence of acidic phospholipids and calcium, FGL2 has prothrombinase activity and acts as a procoagulant. In soluble form, FGL2 promotes T regulatory (Treg) activity and suppresses DC, T, and B cell immune reactivity, acting as an immune suppressor. A 260-280 aa FGL2 complex is thought to be a homotetramer.